literature-review

# Literature Review

## Overview

Conduct systematic, comprehensive literature reviews following rigorous academic methodology. Search multiple literature databases, synthesize findings thematically, verify all citations for accuracy, and generate professional output documents in markdown and PDF formats.

This skill integrates with multiple scientific skills for database access (gget, bioservices, datacommons-client) and provides specialized tools for citation verification, result aggregation, and document generation.

## When to Use This Skill

Use this skill when:
- Conducting a systematic literature review for research or publication
- Synthesizing current knowledge on a specific topic across multiple sources
- Performing meta-analysis or scoping reviews
- Writing the literature review section of a research paper or thesis
- Investigating the state of the art in a research domain
- Identifying research gaps and future directions
- Requiring verified citations and professional formatting

## Core Workflow

Literature reviews follow a structured, multi-phase workflow:

### Phase 1: Planning and Scoping

1. **Define Research Question**: Use PICO framework (Population, Intervention, Comparison, Outcome) for clinical/biomedical reviews
   - Example: "What is the efficacy of CRISPR-Cas9 (I) for treating sickle cell disease (P) compared to standard care (C)?"

2. **Establish Scope and Objectives**:
   - Define clear, specific research questions
   - Determine review type (narrative, systematic, scoping, meta-analysis)
   - Set boundaries (time period, geographic scope, study types)

3. **Develop Search Strategy**:
   - Identify 2-4 main concepts from research question
   - List synonyms, abbreviations, and related terms for each concept
   - Plan Boolean operators (AND, OR, NOT) to combine terms
   - Select minimum 3 complementary databases

4. **Set Inclusion/Exclusion Criteria**:
   - Date range (e.g., last 10 years: 2015-2024)
   - Language (typically English, or sp