Use when formulating clinical research questions (PICOT framework), evaluating health evidence quality (study design hierarchy, bias assessment, GRADE), prioritizing patient-important outcomes, conducting systematic reviews or meta-analyses, creating evidence summaries for guidelines, assessing regulatory evidence, or when user mentions clinical trials, evidence-based medicine, health research methodology, systematic reviews, research protocols, or study quality assessment.
View on GitHubskills/domain-research-health-science/SKILL.md
January 24, 2026
Select agents to install to:
npx add-skill https://github.com/lyndonkl/claude/blob/main/skills/domain-research-health-science/SKILL.md -a claude-code --skill domain-research-health-scienceInstallation paths:
.claude/skills/domain-research-health-science/# Domain Research: Health Science ## Table of Contents - [Purpose](#purpose) - [When to Use](#when-to-use) - [What Is It?](#what-is-it) - [Workflow](#workflow) - [Common Patterns](#common-patterns) - [Guardrails](#guardrails) - [Quick Reference](#quick-reference) ## Purpose This skill helps structure clinical and health science research using evidence-based medicine frameworks. It guides you through formulating precise research questions (PICOT), evaluating study quality (hierarchy of evidence, bias assessment, GRADE), prioritizing outcomes (patient-important vs surrogate), and synthesizing evidence for clinical decision-making. ## When to Use Use this skill when: - **Formulating research questions**: Structuring clinical questions using P ICO T (Population, Intervention, Comparator, Outcome, Timeframe) - **Evaluating evidence quality**: Assessing study design strength, risk of bias, certainty of evidence (GRADE framework) - **Prioritizing outcomes**: Distinguishing patient-important outcomes from surrogate endpoints, creating outcome hierarchies - **Systematic reviews**: Planning or conducting systematic reviews, meta-analyses, or evidence syntheses - **Clinical guidelines**: Creating evidence summaries for practice guidelines or decision support - **Trial design**: Designing RCTs, pragmatic trials, or observational studies with rigorous methodology - **Regulatory submissions**: Preparing evidence dossiers for drug/device approval or reimbursement decisions - **Critical appraisal**: Evaluating published research for clinical applicability and methodological quality Trigger phrases: "clinical trial design", "systematic review", "PICOT question", "evidence quality", "bias assessment", "GRADE", "outcome measures", "research protocol", "evidence synthesis", "study appraisal" ## What Is It? Domain Research: Health Science applies structured frameworks from evidence-based medicine to ensure clinical research is well-formulated, methodologically sound, and clinic